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Purvalanol A

CAS No. 212844-53-6

Purvalanol A ( NG-60;NG 60;NG60 )

Catalog No. M13387 CAS No. 212844-53-6

A potent, cell-permeable, selective inhibitor of CDK with IC50s of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 30 In Stock
10MG 41 In Stock
25MG 69 In Stock
50MG 113 In Stock
100MG 186 In Stock
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Biological Information

  • Product Name
    Purvalanol A
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, cell-permeable, selective inhibitor of CDK with IC50s of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.
  • Description
    A potent, cell-permeable, selective inhibitor of CDK with IC50s of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively; also inhibits Saccharomyces cerevisiae Cdc28p (IC50=80 nM) and has no effect on PKC, Raf, CK1, CK2.
  • Synonyms
    NG-60;NG 60;NG60
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    Cdc2/CyclinB;CDK2/CyclinA;CDK2/CyclinE;CDK4/CyclinD1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    212844-53-6
  • Formula Weight
    388.89
  • Molecular Formula
    C19H25ClN6O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC(C)[C@@H](NC1=NC(NC2=CC=CC(Cl)=C2)=C3N=CN(C(C)C)C3=N1)CO
  • Chemical Name
    1-Butanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gray NS, et al. Science. 1998 Jul 24;281(5376):533-8.
2. Chadebech P, et al. Int J Cancer. 2000 Sep 15;87(6):779-86.
3. Obakan P, et al. Mol Biol Rep. 2014 Jan;41(1):145-54.
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