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Purvalanol A
CAS No. 212844-53-6
Purvalanol A ( NG-60;NG 60;NG60 )
Catalog No. M13387 CAS No. 212844-53-6
A potent, cell-permeable, selective inhibitor of CDK with IC50s of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 30 | In Stock |
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| 10MG | 41 | In Stock |
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| 25MG | 69 | In Stock |
|
| 50MG | 113 | In Stock |
|
| 100MG | 186 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePurvalanol A
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, cell-permeable, selective inhibitor of CDK with IC50s of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.
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DescriptionA potent, cell-permeable, selective inhibitor of CDK with IC50s of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively; also inhibits Saccharomyces cerevisiae Cdc28p (IC50=80 nM) and has no effect on PKC, Raf, CK1, CK2.
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SynonymsNG-60;NG 60;NG60
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PathwayAngiogenesis
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TargetCDK
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RecptorCdc2/CyclinB;CDK2/CyclinA;CDK2/CyclinE;CDK4/CyclinD1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number212844-53-6
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Formula Weight388.89
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Molecular FormulaC19H25ClN6O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC(C)[C@@H](NC1=NC(NC2=CC=CC(Cl)=C2)=C3N=CN(C(C)C)C3=N1)CO
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Chemical Name1-Butanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gray NS, et al. Science. 1998 Jul 24;281(5376):533-8.
2. Chadebech P, et al. Int J Cancer. 2000 Sep 15;87(6):779-86.
3. Obakan P, et al. Mol Biol Rep. 2014 Jan;41(1):145-54.
2. Chadebech P, et al. Int J Cancer. 2000 Sep 15;87(6):779-86.
3. Obakan P, et al. Mol Biol Rep. 2014 Jan;41(1):145-54.
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